San Polo d'Enza (Reggiano: Sân Pôl) is a comune (municipality) in the Emilia-Romagna region of Northern Italy, located about 70 kilometres (43 mi) west of Bologna and about 20 kilometres (12 mi) southwest of Reggio Emilia.

San Polo d'Enza borders the following municipalities: Bibbiano, Canossa, Montecchio Emilia, Montechiarugolo, Quattro Castella, Traversetolo, Vezzano sul Crostolo.

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