Guaymallén is a central department of Mendoza Province in Argentina.

The provincial subdivision has a population of about 250,000 inhabitants in an area of 164 km2 (63 sq mi), and its capital city is Villa Nueva, which is located around 1,090 km (680 mi) from Buenos Aires.

The three main sectors of the economy are banks and financial institutions, the service sector, and industry and manufacturing.

Guaymallén Department is divided into 20 districts:

This article about a place in Mendoza Province, Argentina is a stub.