Guenoc is a former settlement in Lake County, California.

[1] It was located in the Coyote Valley 4 miles (6 km) northeast of Middletown,[2] at an elevation of 968 feet (295 m).

[2] The Guenoc region was planted with vineyards in the 1880s, where Burgundy varietals were grown.

Thoroughbred horses were also raised in the area, where actress Lillie Langtry lived for a time on a still-extant ranch.

[3] In 2020, the Guenoc Valley was approved as the site of a large rural mixed-use housing development, the Guenoc Valley Project.