Not having a suitable arena for this league, the club moved to the nearby indoor stadium in Cremona Cà de Somenzi, keeping the seat in Soresina.

The first year in Legadue, Gruppo Triboldi finished the regular season in fourth place, being eliminated in the first round of the playoffs by Pavia.

At the end of the season Trinchieri left the role of head coach and moved to Caserta, being replaced by Stefano Cioppi.

At the end of the first season in Serie A, ended with the 13th place in the standings, the General Manager Ario Costa and Vice President Matteo Bonetti left the team to join Leonessa Brescia in Serie A Dilettanti, the third Italian league, so the owner Secondo Triboldi decided to appoint as General Manager Flavio Portaluppi, who had played in the team just two seasons before, after a year spent at Olimpia Milano.

At the end of the 2010-11 season, after the club achieved the 12th place, the President Secondo Triboldi resigned from his office and gave his titles away for free.

In Cremona arrived among the others Jonathan Tabu, replacing E. J. Rowland, passed meanwhile to Unicaja Malaga and especially Von Wafer, who had previously played in the NBA.

Because of these results, after only a month Tomo Mahorič was fired and in its place arrived Attilio Caja, former coach of Cremona in the second half of the 2009-10 season.

In the first days of December the team's top scorer, Von Wafer, returned in the NBA as a result of the end of the lockout.

In the summer the club had to face an economic crisis which seemed to prevent the team to play in the top Italian League the following year.

The team acquired some prestigious players such as Jason Rich, the hero of the 2011-12 season and Ben Woodside, who had been the previous year the best assistman throughout Europe.

[3] On 12 July 2020, Vanoli Basket announced the club intended to leave the LBA after a period of 11 years due to a lack of economic support.