[8] Jina Moore served as Editor-in-Chief and co-Publisher until April 2024, when she resigned over the magazine's decision to stand by the retraction of the essay, which she had selected for publication.

[21] Contributors include Lorraine Adams, Chimamanda Ngozi Adichie, Jesse Ball, A. Igoni Barrett, Amit Chaudhuri, Susan Choi, Noam Chomsky, Billy Collins, Susan Daitch, Marguerite Duras, Stephen Elliott, Rivka Galchen, James Galvin, Amitav Ghosh, Mahvish Khan, Alexandra Kleeman, Eric Kraft, Kiese Laymon, Douglas Light, Sarah Lindsay, Dorthe Nors, Okey Ndibe, Meghan O'Rourke, Zachary Mason, Tracy O'Neill, Daniele Pantano, Matthew Rohrer, Deb Olin Unferth, Sergio Ramírez, Amartya Sen, Aurelie Sheehan, Jonathan Steele, Laren Stover, Terese Svoboda, Mitch Swenson, Olufemi Terry, Anthony Tognazzini, Frederic Tuten, Joe Wenderoth Patrick White, and Yaa Gyasi.

Guest fiction and poetry editors have included Alexander Chee, Roxane Gay, Francisco Goldman, Randa Jarrar, Sam Lipsyte, Ben Marcus, Claire Messud, George Saunders, Tracy K. Smith, and Frederic Tuten.

Interview subjects have included filmmaker John Waters, Congressman John Conyers, Congresswomen Marcy Kaptur and Carolyn B. Maloney, Costa Rican President Óscar Arias, Justice Department legal counsel John Yoo, former member of Dutch Parliament Ayaan Hirsi Ali, former Iraqi cabinet member Ali Allawi, artist Chuck Close, singers Lila Downs and David Byrne, and authors Etgar Keret, Andrew Bacevich, Don DeLillo,[22] Howard Zinn, Samantha Power, Bernard-Henri Lévy, Nicholas D. Kristof, Joan Didion, playwright Tony Kushner, and actor Mia Farrow.

[23] In March 2024, during the Israel–Hamas war, at least 10 editors of Guernica resigned over its publication of an essay, titled "From the Edges of a Broken World",[24] by Israeli poet, translator and essayist[25] Joanna Chen, which the magazine later retracted at the author's invitation.

[27] Guernica co-publisher Madhuri Sastry, who was among those who quit over the affair, criticized the essay as "a hand-wringing apologia for Zionism and the ongoing genocide in Palestine".