GuideWell, formally GuideWell Mutual Holding Corporation (holding company for Florida Blue), is a mutual insurance holding company primarily focused on health insurance in Florida.

[4] By health insurance premiums written, it is 10th largest in providing health insurance in the United States with about $15b in health insurance sales.

[5]: 70 It originally formed out of Florida Hospital Service Corporation founded in 1944, which became Blue Cross of Florida, and Florida Medical Services Corporation in 1946, which became Blue Shield of Florida.

[8] In 2022, GuideWell acquired Triple-S, which operated Blue Cross Blue Shield plans in Puerto Rico.

[9] The holding company controls corporations operating in insurance, health care providers, consumerism, and government.