He founded the Orde van den Prince on 2 November 1955, and was its president from 1955 until 1964.
Since July 1965 he bears the honorary title of President Founder of the Orde van den Prince.
Guido Van Gheluwe went to high school at the St. Amandscollege in Kortrijk, where he graduated in 1946.
From 2 November 1966 until 24 September 1971 he was the secretary-general of the non-profit organization Economic Council for Flanders (Dutch: Economische Raad voor Vlaanderen, E.R.V.).
He is professor emeritus of the Hoger Instituut voor Bestuurswetenschappen in Antwerp, where he taught from 1 October 1978 until 31 April 1986.