Guilford is a village in southeastern Nodaway County, Missouri, United States, near the Platte River.

[4] The community was named in commemoration of the Battle of Guilford Court House in the American Revolutionary War.

According to the United States Census Bureau, Guilford has a total area of 0.09 square miles (0.23 km2), all land.

33.3% of all households were made up of individuals, and 8.4% had someone living alone who was 65 years of age or older.

32.4% of all households were made up of individuals, and 23.5% had someone living alone who was 65 years of age or older.

There were 25.0% of families and 28.6% of the population living below the poverty line, including 40.0% of under eighteens and 25.0% of those over 64.

The high school, grades 7-12, was in Barnard, five miles west of town.