He made his first team debut on 21 April 2013, coming on as a second half substitute for goalscorer Edigar Junio in a 3–1 Campeonato Paranaense home win against fierce rivals Coritiba.

[2] Returning to Furacão in July 2016, Guilherme made his Série A on 6 October by replacing Lucho González in a 3–1 home win against Chapecoense.

[4] On 25 July 2022, he signed a one-year loan deal with Grasshopper in the Swiss Super League.

On 20 August 2022, he scored two goals in his first game, a Swiss Cup match against a team from the 4th tier, after coming on in the 61st minute.

[6] On 6 July 2023, Schettine signed with the Russian Premier League club Ural Yekaterinburg.