Guilherme de Brito Bollhorst was born in Vila Isabel, a traditional neighborhood with regard to samba, the home of 12 years older Noel Rosa, with whom he was acquainted and who often gave him rides on his car.
Guilherme de Brito wrote 153 songs, the great majority being sambas, almost all of them in partnership, being 75 with Nelson Cavaquinho.
They were recorded by many samba artists besides himself, such as Cartola, Elizeth Cardoso, Paulinho da Viola and especially Beth Carvalho, who had a great reverence for the work of the duo Guilherme de Brito-Nelson Cavaquinho.
Some of their most famous songs include "A Flor e O Espinho", "Quando eu me Chamar Saudade", "Pranto de Poeta", "Folhas Secas" and "Minha Festa".
As a painter, Guilherme de Brito has his works exhibited in galleries across Brazil, the United States, Japan and Australia.