Guillaume shared the screen with his father several times throughout his career, beginning with his first film role, aged three, playing Gérard's son in Claude Goretta's That Wonderful Crook (Pas Si Méchant Que Ça) in 1974.

Depardieu was known to have had a strained relationship with his famous father, which he detailed in his 2004 autobiography Tout Donner (Giving Everything).

By 1993, he had already served two jail sentences for drug offences, which included dealing heroin and theft.

[4] Depardieu's health was compromised by drug addiction and by his 1995 motorcycle accident and subsequent surgeries.

[1] He contracted a severe viral pneumonia, caused by MRSA, while filming The Childhood of Icarus (L'Enfance d'Icare).