He traveled across the Mediterranean, notably to Italy, Palestine, Syria, and Egypt,[2] visiting centers of medical scholarship such as the Schola Medica Salernitana.
Having expanded his knowledge, he returned to his homeland, Picardy, where, in the course of the plague epidemics of the Black Death, he gained a reputation as one of the best doctors in France.
Thus, he became the personal physician of the powerful feudal lord Enguerrand VII de Coucy.
When king Charles VI of France suffered a nervous breakdown in August 1392 near Le Mans, during a campaign against Brittany, unexpectedly attacked his own companions, killing some of them and falling into a coma himself, he was already abandoned by his doctors.
[3] Harcigny died in his home in Laon, France, in 1393, at 93 years of age.