He is currently the Thomas D. Spies Professor of Lymphatic Metabolism at Northwestern University, and director of the Center for Vascular and Developmental Biology at the Feinberg Cardiovascular Research Institute.
[5] In 1996 he began working in the Department of Genetics at St. Jude Children's Research Hospital in Memphis, as a faculty member.
[6][7] In 2015 he was named the Thomas D. Spies Professor of Lymphatic Metabolism at Northwestern University in the Department of Medicine in the Division of Nephrology and Hypertension, and he is also the director of the Center for Vascular and Developmental Biology at the Feinberg Cardiovascular Research Institute.
[11][12] His laboratory also identified Six2 as a critical gene in the process of generation of nephron progenitors[13] and demonstrated that Six3 activity was required for the formation of the mammalian forebrain and neuroretina in mice.
[8] In 2020, he published his research on the role of the Reelin protein promotes cardiac regeneration and repair by reducing cell death after heart injury in the journal Nature.