Eminem's 2024 album The Death of Slim Shady (Coup de Grâce) features a sequel to the song called "Guilty Conscience 2".

The concept for "Guilty Conscience" first arose whilst Dr. Dre and Eminem were at the gym together and discussing potential song ideas.

[3] Writing for Entertainment Weekly, David Browne noted that Eminem's "coldly-calculated-to-offend alter ego considers date rape".

[4] The video for "Guilty Conscience" has a nonstop back-beat with a chorus, unlike the album version, and a different narrator, played by actor Robert Culp.

The version that aired on MTV eliminated the murder at the end of the song and converted it into an escalating argument between Eminem and Dre with no resolution.

[5] The music video is produced using the bullet time technique, depicting Eminem and Dr. Dre rapping to the song's protagonists on how to deal with their conflicting situations: including a man's temptation to robbing a liquor store, a college student's urge to have sex with an underage girl at a frat party, and the urge of a construction worker to murder his wife after he catches her cheating with another man.