"Natural Born Killaz" is a collaborative single released by Dr. Dre and Ice Cube for the soundtrack of the film Murder Was the Case.

The production credits features Soopafly on the keyboards and Nanci Fletcher, Danette Williams and Barbara Wilson on vocals.

The song references such subjects as mass murder, Sarah Connor from the Terminator films, Al Cowlings' tight bond with O. J. Simpson, schizophrenia, Charles Manson, the attack on Reginald Denny during the Rodney King riots, strychnine poisoning, Michael P. Fay's caning in Singapore, Jeffrey Dahmer, Kurt Cobain's suicide and psilocybin mushrooms.

The album song portrays a couple (performed by Priest ‘Soopafly’ Brooks and Nanci Fletcher) walking down the street until, from a distance, they are yelled at and verbally insulted by a local thug.

The final shot of the video features a cameo from rapper and actor Tupac Shakur, prior to his association with Death Row Records, as a SWAT sniper who takes out Ice Cube's character.