The delegation consisted of two athletes, Cesar Lopes Cardoso and Ussumane Cande, who both competed in track and field events.

Guinea-Bissau, a country in West Africa, first participated in a Summer Olympics at the 1996 Games in Atlanta, United States.

[1] They participated on five occasions up to and including the 2012 Summer Olympics in London but failed to win any medals along the way.

[1] Members representing Guinea-Bissau joined the International Paralympic Committee in 1997, but did not attend the IPC General Assembly that year.

[10] In the 400 metres, Cande was due to race in the final (the event had no heats) but did not; it was won by Cuban Yunidis Castillo.