The Gulf of Taranto (Italian: Golfo di Taranto; Tarantino: Gurfe de Tarde; Latin: Sinus Tarentinus) is a gulf of the Ionian Sea, in Southern Italy.

The Gulf of Taranto is almost square, 140 km (87 mi) long and wide, making it the largest gulf in Italy, and it is delimited by the capes Santa Maria di Leuca (to the east, in Apulia) and Colonna (the ancient Lacinium, to the west, in Calabria), encompassed by the three regions of Apulia, Basilicata and Calabria.

The most important rivers are the Basento, the Sinni, and the Agri.

Also the Greek colonies (Magna Graecia) of Kroton, Heraclea, Thurii, and Sybaris were founded on the Gulf of Taranto.

Italy claims the whole gulf as national waters, thus closed to international traffic.