Uecker met the group ZERO with Heinz Mack and Otto Piene in 1960, artists who propagated a new beginning of art in opposition to the German Informel.

He occupied himself with the medium of light, studied optical phenomena, series of structures and the realms of oscillation that actively integrate the viewer and enable him to influence the visual process by kinetic or manual interference.

Uecker, Mack and Piene began working together in joint studios at the Stedelijk Museum in Amsterdam in 1962 and installed a 'Salon de Lumière' at the Palais des Beaux-Arts in Paris.

[3] He had his first solo exhibition in the United States at the Howard Wise Gallery on West 57th Street, showing important work such as the kinetic New York Dancer I (1966).

His first solo show since 1968 took place early 2021 at the Lévy Gorvy gallery in Paris,[5] called Lichtbogen, where he presented a new set of art inspired by a visit to an island in the Straits of Ormuz.