[1][2] Guo Jiakun graduated from Nankai University in Tianjin in 2002 with a bachelor's degree in English, with a concentration on foreign trade.

He served as third secretary of the Permanent Mission of the People's Republic of China to the United Nations, as deputy director of the Fourth Division of the MFA Department of African Affairs, and as director of the MFA Policy Planning Department.

[5][6] On 6 January 2025, Guo Jiakun was appointed as the 35th spokesperson of the Ministry of Foreign Affairs and conducted a regular press conference on the same day.

[7][8] In January 2025, as TikTok American users migrated to Chinese social media app RedNote, Guo responded to the question of Chinese censorship and replied that "no matter what platforms you use, it’s a personal choice."

[9] After President Donald Trump signed an executive action to delay the ban on TikTok for 75 days, he stated in a press briefing that the U.S. should listen "to the voice of reason" and "provide an open, fair, just and non-discriminatory business environment" for companies from all countries.