[5] He is currently the Poitras Professor of Neuroscience and the Director of Model Systems and Neurobiology in the Stanley Center for Psychiatric Research at Broad Institute.

[5] Feng studies mutations of the postsynaptic density (PSD), the protein scaffold which stabilizes neurotransmitter receptors, permits normal function of the synapse, and participates in synaptic plasticity.

He has also shown that mutations in SHANK3, associated with Phelan McDermid syndrome (PMS), lead to autism-like symptoms such as repetitive behaviors, sensory hyper-sensitivity, and social deficits in mice.

In 2016, Feng showed that gene therapy to restore normal SHANK3 function in adult mice could reverse some behavioral symptoms.

In 2018, Feng and colleague Robert Desimone received a grant of over $2.3 million USD to correct MECP2 mutations, which are the cause of Rett syndrome.