Close to Guspini, at the mines of Montevecchio and Gennamari, galena and sphalerite were extracted in the past.

Today the people at Guspini are concentrated on agriculture, on tourism and on smaller to middle enterprises.

Close to Guspini are some well-built nuraghes and the Phoenician-Punic archaeological site of Neapolis.

Traces of Nuragic, Phoenician-Punic, Bizantine and Roman settlements have been found.

The town has a medieval structure with the Church of Santa Maria of Malta which was founded by the knights of the same order, as the most ancient trace.