Gustave F. Perna (born 15 April 1960)[1] is a retired United States Army four-star general who last served as the chief operating officer of the federal COVID-19 response for vaccine and therapeutics.

As chief operating officer of COVID-19 response, he oversaw the logistics in the United States federal government's distribution of the vaccine to the COVID-19 pandemic.

[6] In March 2020, his deputy Lieutenant General Edward M. Daly was confirmed as his successor at AMC.

[11][12] In June 2020, he was nominated to continue serving as an Army general in the position of COO, and was confirmed the next month by the Senate.

[3] According to Politico's "National Security Daily" newsletter of 27 October 2022, "Retired Gen. GUSTAVE PERNA will serve as chief operating officer of DEFCON AI, a startup that will bring artificial intelligence to defense logistics.