[1] The company started marketing self-help products endorsed by Fran Tarkenton and motivational speaker Tony Robbins, previous products also included exercise equipment such as a pilates program, called the "Malibu Pilates system", endorsed by actress Susan Lucci and Instant Abs by model Heidi Klum.

[2][3][5] At the time many infomercials mimicked talk shows and investigative news specials, raising concerns among consumers and policy makers that the programs were misleading.

[7] Renker was invited to testify to a Congressional subcommittee in 1990 regarding ethics in advertising, which led Guthy-Renker and others to form the National Infomercial Marketing Association to create industry standards.

[3][7][8] The following year, the firm had to cut back operations, because news coverage of the Persian Gulf War drew viewers away from infomercials.

In 1998, a Japanese trading company, Nissho Iwai Group, bought a 17 percent portion of Guthy-Renker's Asia subsidiary for $9 million.

[13] Guthy-Renker created a television station for infomercials called GRTV in 1996, which was sold to TVN Entertainment Corporation in 1999.

[5] Guthy-Renker partnered with National Media Corp. to help market some of its fitness products, which led to a legal dispute that was settled with undisclosed terms in 1997.

Guthy-Renker claimed National Media Corp. excessively aired infomercials for an exercise machine, the Fitness Flyer, and started selling an unauthorized imitation of the original.

[28] Guthy-Renker markets the "Meaningful Beauty" anti-aging skin care system endorsed by model/actress Cindy Crawford and developed by Algerian-French cosmetic surgeon and chemist Jean-Louis Sebagh.

[32] In January 2015, it was announced that actress Brooke Shields would endorse Wen Hair Care developed by Chaz Dean.

In 2016, a joint-venture was entered into with Nestlé Skin Health, which acquired a majority stake in Guthy-Renker's European business.