Changing uses and repeated damages by war and conflicts led to alterations and rebuilding of the area through the centuries.

From 1845 till 1848, the first railway from Kassel to Bebra was built, bringing a direct connection from Guxhagen to the wider area.

In the mid of the 20th century, an Autobahn connection was built.From 1664-1941, there were Jewish families living in Guxhagen who formed their own community and built a synagogue and school.

In connection with the November pogrom, eleven Jewish men and a boy were arrested and brought to Breitenau concentration camp.

(as of municipal elections held in 2021) Guxhagen lies on Federal Highway (Bundesstraße) B 83 and Autobahn A 7 (Kassel – Bad Hersfeld).