Guy Despard Goff (September 13, 1866 – January 7, 1933) was an American lawyer and politician - who served as a United States senator from West Virginia.

Born in Clarksburg, West Virginia, he attended the common schools and the College of William and Mary.

He graduated from Kenyon College (in Gambier, Ohio) in 1888 and from the law department of Harvard University in 1891; he was admitted to the bar the same year and commenced practice in Boston, Massachusetts.

In 1893 he moved to Milwaukee, Wisconsin, and continued the practice of law; he was elected prosecuting attorney of Milwaukee County in 1895, ran for mayor in 1904 and, in 1911, he was appointed United States Attorney for the Eastern District of Wisconsin by President William Howard Taft.

Goff was appointed special assistant to the Attorney General of the United States in 1917, and, during World War I, he was commissioned a colonel in the Judge Advocate General's Department of the United States Army and served in France and Germany in 1918-1919.