Born in Brazil to American parents, Ecker became a household name in Latin America for his portrayal of Sebastián Vallejo in the Colombian telenovela Café, con aroma de mujer.

American viewers may be familiar with him through his work on the television show Las Vegas as Detective Luis Perez.

He is the third out of five children (three girls, two boys) of American parents Marion and Bob Ecker.

His father was a businessman, originally from Wisconsin, who worked for several multinational companies and, during his childhood, Ecker also lived in Colombia, Venezuela and Mexico.

On June 24, 2013, it was confirmed that Guy Ecker (along with Susana González) would star as the protagonist in the Mexican telenovela Por siempre mi amor.