Hocquenghem was a prominent member of the Front homosexuel d'action révolutionnaire (FHAR), originally formed by lesbian and feminist activists who split from the Mouvement Homophile de France in 1971.

Only two of his theoretical tracts, Homosexual Desire (1972) and L'Après-Mai des faunes (1974), and his first novel, L'Amour en relief (1982), have been translated into English.

was shown at the Roxie Cinema in San Francisco in April 1980 and released in America as The Homosexual Century, like Hocquenghem, the film is virtually unknown.

Drawing on the theories of desiring-production developed by Gilles Deleuze and Félix Guattari in their Anti-Oedipus (1972), Hocquenghem critiqued the influential models of the psyche and sexual desire derived from the psychoanalysts Jacques Lacan and Sigmund Freud.

Additionally, Hocquenghem wrote the following works: The Screwball Asses (Les Culs Énergumènes) is an essay that originally appeared in the 12th (March 1973) issue of Recherches, a French journal.

[11] The Screwball Asses is a critique of various issues in left-wing politics and gay culture, using Marxist and Freudian vocabulary: We would be beating a dead horse by saying that psychoanalysis trumpets the existence of homosexuality everywhere.

The homosexual prohibition enables and organizes all social sentiments concerning the cell, the group, the tribe, the company, the union, and the homeland.The author describes the "ghetto" of gay male life in 1970s France, which in his account is often confined to cruising in public restrooms.

He also explains gay male archetypes and binaries (e.g. "uber-male or sub-male, black or white, Arab or Viking, top or bottom, and so forth"[14]) as forms of mimicry which are caused by heteronormative socialization with heterosexuals, which in turn is informed by capitalism.