The Guy M. and Rose (Freeman) Gillette House is a historic building located in Cherokee, Iowa, United States.

It is significant because of its association with Guy Gillette, who resided here while he served in the United States Senate.

Here he would meet with constituents, give public presentations, and participate in various activities when the Senate was in recess.

Gillette also lived here when he served as president of the American League for a Free Palestine, and in his post-political life.

This article about a property in Cherokee County, Iowa on the National Register of Historic Places is a stub.