Concordia University's Integrated Engineering, Computer Science and Visual Arts Complex is located on this street, as is the John Molson School of Business building.

The street was named on August 30, 1817 for Étienne Guy (1774–1820), a notary and member for the riding of Montreal in the Lower Canada Assembly.

[1][2] Guy Street constituted the link between the Faubourg Saint-Joseph and Saint-Antoine.

Since 1869, the Grey Nuns have had a convent on Guy Street, at the corner of Dorchester Boulevard.

[3] From 1898 to 1963, the street was home to Her Majesty's Theatre, a key performing arts venue.