The 1.3 km long six-lane street passes City Hall Square on its way from Jarmers Plads, a junction just north of Vesterport station, to Lange Bridge which connects it to Amager Boulevard on Amager.

From Jarmers Plads traffic continues along Gyldenløvesgade which on the far side of The Lakes splits into Aaboulevard and Rosenørns Allé.

At the City Hall Square the boulevard meets Vesterbrogade, another very busy and importaint street.

In 1890, Vestre Boulevard was laid out as a green promenade with an abundance of trees and flowers where the city's bourgeoisie would stroll in peaceful surroundings.

In 1954, a new Lange Bridge opened as a direct continuation of Vestre Boulevard to release the pressure on the more narrow Vester Voldgade.