5DZO, 5F7026762171283ENSG00000113249ENSMUSG00000040405Q96D42Q5QNS5NM_001099414NM_001173393NM_001308156NM_012206NM_001166631NM_001166632NM_134248NP_001166864NP_001295085NP_036338NP_001160103NP_001160104NP_599009Hepatitis A virus cellular receptor 1 (HAVcr-1) also known as T-cell immunoglobulin and mucin domain 1 (TIM-1) is a protein that in humans is encoded by the HAVCR1 gene.

The hepatitis A virus cellular receptor 1 (HAVCR1/TIM-1), is a member of the TIM (T cell transmembrane, immunoglobulin, and mucin) gene family, which plays critical roles in regulating immune cell activity especially regarding the host response to viral infection.

[6] Subsequently, it was demonstrated that members of the TIM gene family including TIM-1 participate in host immune response.

[13] Infectious HAV-containing exosomes are internalized by HAVCR1, but true entry into the cytosol is achieved through fusion with NPC1.

Moreover, reducing expression of endogenous TIM-1 in highly permissive cell lines decreased Ebola virus infectivity.

TIM-1 directly interacted with Dengue virus particle by recognizing PS on the virion surface.