The immunoglobulin domain, also known as the immunoglobulin fold, is a type of protein domain that consists of a 2-layer sandwich of 7-9 antiparallel β-strands arranged in two β-sheets with a Greek key topology,[1][2] consisting of about 125 amino acids.

The cross-overs between sheets form an "X", so that the N- and C-terminal hairpins are facing each other.

Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions.

Examples include antibodies, the giant muscle kinase titin, and receptor tyrosine kinases.

[3] Human genes encoding proteins containing the immunoglobulin domain include: