The serotype identifies certain B*15 gene-allele protein products of HLA-B.
B75 (B*1502) is associated with a severe drug-induced skin condition in ethnic East Asians.
[2] HLA-B*1502 is associated with carbamazepine and phenytoin–induced Stevens–Johnson syndrome in Chinese and Thai people.
[2][5][6] One study showed a 100% association between B*1502 and the drug-induced skin disorder in a Chinese population.
[5] In Europe the B*1502 positive patients are only found in this syndrome of persons of East Asian descent, however B58 confers susceptibility to both groups but to a lesser degree and is sensitive to allopurinol.