1HDM, 2BC4, 4FQX, 4GBX310814998ENSG00000241394ENSG00000243189ENSG00000242685ENSMUSG00000037649P28067P28078Q31621NM_006120NM_010386NM_001360530n/aNP_034516NP_001347459HLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the HLA-DMA gene.

[5][6] HLA-DMA belongs to the HLA class II alpha chain paralogues.

This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane.

DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site.

The alpha chain is approximately 33-35 kDa and its gene contains 5 exons.