4I0P311215002ENSG00000241106ENSMUSG00000041538P13765n/aNM_002120NM_010389NP_002111n/aHLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene.

[5] HLA-DOB belongs to the HLA class II beta chain paralogues.

This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane.

DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM.

The beta chain is approximately 26-28 kDa and its gene contains 6 exons.