1JK8, 1S9V, 2NNA, 4GG6, 4OZF, 4OZG, 4OZH, 4OZI311714960ENSG00000228284ENSMUSG00000036594P01909P04228P14436P04227NM_002122NM_010378NP_002113NP_034508Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 (6p21.3) and also denotes the genetic locus which contains this gene.

HLA-DQA1 belongs to the HLA class II alpha chain paralogues.

This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane.

It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

DQ1 is a serotype, rare among serotypes for human class II antigens, in that the antibodies to DQ1 react to the alpha chain of HLA DQ, these DQA1 allele gene products.