3126n/an/an/aP13762n/aNM_021983n/aNP_068818n/aMajor histocompatibility complex, class II, DR beta 4, also known as HLA-DRB4, is a human gene.

[2] The protein encoded by this gene belongs to the HLA class II beta chain paralogues.

The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane.

It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.