She served on MARLANT missions protecting Canada's sovereignty in the Atlantic Ocean and enforcing Canadian laws in its territorial sea and Exclusive Economic Zone.

Iroquois was deployed on missions throughout the Atlantic and to the Indian Ocean; specifically the Persian Gulf and Arabian Sea on anti-terrorism operations.

Iroquois deployed to the Adriatic Sea from 25 September 1993 to 25 April 1994 as part of the blockade force enforcing sanctions on Yugoslavia.

Iroquois was later incorporated into a US amphibious ready group for escort duties for United States Marine Corps transports positioned close to Pakistan.

In order to accommodate the request, MARLANT reassigned Fredericton's helicopter and aircrew to Iroquois, allowing the destroyer to sail on 24 February.

[14] In 2008 Iroquois, Calgary and Protecteur were deployed to the waters off Somalia as part of CTF 150, the multi-national task force that concerned itself with drug and people smuggling and piracy in the region.

[15] In 2012, Iroquois was among the Canadian warships sent to the Caribbean Sea to help stem the flow of illegal drugs into North America as part of Operation Caribbe.

[16] After rust was found in a machinery space, coupled with structural cracks in the hull of the destroyer, Iroquois was laid up at Halifax in mid-April 2014.

[18][19] On 24 November 2016 the destroyer was towed out of Halifax harbour en route to Liverpool, Nova Scotia to be broken up for scrap.