HMS Defiance was a 64-gun third rate ship of the line of the Royal Navy, built by Phineas Pett II at Chatham Dockyard, and launched in 1675.

[2] Defiance was part of a squadron under Vice-Admiral John Benbow in August 1702.

In an action between Benbow's squadron and the squadron of the French Admiral Jean du Casse, Defiance under Captain Richard Kirkby was one of the ships that refused to engage.

Along with Windsor, Defiance bore away from the French squadron after only two or three broadsides, and stood out of range.

At his court-martial, Captain Kirkby was convicted of cowardice and sentenced to be shot.