In response to the French invasion of Belgium in the War of the First Coalition, at the end of 1792, she took part in the Scheldt expedition that was foiled by ice in the estuary.

While operating in the English Channel, Iphigenia captured the French privateer Elizabeth on 16 February 1793.

In response to the French campaign in Egypt and Syria, Iphegenia was fitted out as a troopship in 1800 at Portsmouth.

She had been to Cyprus to fetch water and timber but on 20 July 1801, shortly after her return to Alexandria, she was discovered to be on fire.

[3] Because Iphigenia served in the navy's Egyptian campaign (8 March to 8 September 1801), her officers and crew qualified for the clasp "Egypt" to the Naval General Service Medal, which the Admiralty issued in 1847 to all surviving claimants.