She spent her career on counter piracy patrols and trade protection duties in Home Waters, the Mediterranean and in North America and the West Indies.

[6] HMS Lyme was commissioned in April 1695 under the command of Captain William Caldwell, he had been appointed by Admiralty Order (AO) 15 March 1695.

On 27 May 1695, Captain John Ward assumed command for service in Lord Berkeley's Squadron attacking the coastal ports of France.

Captain Letchmere was mortally wounded on 15 January 1704 while in action against a 46-gun privateer off Deadman Head.

She suffered 36 killed and wounded and so damaged she could not pursue the French ship when they broke off.

[8] On 19 January 1704 she was under Captain George Doleman until he was killed on 23 March 1705 then Commander Robert Coleman (promoted Captain in September 1705) for service in the Mediterranean and Sir Cloudesley Shovell's Fleet in 1706.

On her return to Home Waters she underwent a middling repair costing £1,624.4.1.25d (accounting for inflation £296,600) at Deptford from July to November 1714.

She was recommissioned under Captain Ellis Brand for service at Virginia until 1719 when she returned to Home Waters.

[2] She was ordered on 4 November 1718 to be rebuilt at Deptford Dockyard under the guidance of Master Shipwright Richard Stacey.

Her keel was laid (old ship dismantled) in February 1720 and launched on 8 November 1720.

[10] HMS Lyme was commissioned in May 1721 under the command of Captain Lord Vere Beauclerk (until 1727).