San Nicolás was an 80-gun third-rate ship of the line of the Spanish Navy.

She was present at the Battle of Cape St Vincent on 14 February 1797, when she was boarded by a number of British sailors from HMS Captain led by Horatio Nelson.

Admiral Sir John Jervis put Commander Peter Puget, in HMS Raven in charge of San Nicolas, still crewed by Spaniards.

Puget suppressed a mutiny and delivered the crew to Lisbon.

She became a prison ship in 1800, and was sold for breaking up on 3 November 1814.