Sceptre and Albion left Rio de Janeiro on 13 October, escorting Lord Melville, Earl Spencer, Princess Mary, Northampton, Anna, Ann, Glory, and Essex.

[2] On 28 February 1804, Albion and Sceptre met up in the straits of Malacca with the fleet of Indiamen that had just emerged from the Battle of Pulo Aura and conducted them safely to Saint Helena.

Sceptre then returned home in 1808 accompanied by two homeward-bound Danish East Indiamen that Captain Bingham had captured off the Cape of Good Hope.

On 18 December, Sceptre, Blonde, Thetis, Freya, Castor, Cygnet, Hazard, Ringdove, and Elizabeth proceeded to attack two French flûtes, Loire and Seine anchored in Anse à la Barque ("Barque Cove"), about nine miles (14 km) to the northwest of the town of Basse-Terre.

Blonde, Thetis and the three sloops bore the brunt of the attack but forced the French to abandon their ships and set fire to them.

In 1847 the Admiralty awarded the Naval General Service Medal with clasp "Anse la Barque 18 Decr.

Towards the end of January 1810 Sceptre escorted a division of the troops destined for the attack on Guadeloupe from St. Lucia to the Saintes.

In 1813, Captain Charles Ross, took command of Sceptre as the flagship of Rear Admiral Sir George Cockburn for operations against the United States.

On 11 July 1813, Sceptre, with Romulus, Fox, Nemesis, and Conflict and the tenders Highflyer and Cockchafer, anchored off the Ocracoke bar, in the Outer Banks of North Carolina.

An advanced division of the best pulling boats commanded by Lieutenant Westphall and carrying armed seamen and marines from Sceptre attacked the enemy's shipping.

[8] The capture and recapture of Fanny, together with Sceptre's claim for salvage, gave rise to several important legal cases.