On 29 February 1808 Tweed captured the Spanish letter of marque schooner Santissima Trinidad.

[a] In June Captain William Pryce Cumby received command of a squadron consisting of Polyphemus, Aurora, Tweed, Sparrow, Thrush, Griffon, Lark, Moselle, Fleur de la Mer, and Pike.

They sailed from Port Royal on 7 June with troops under Major-General Hugh Lyle Carmichael to assist the Spanish forces besieging the French in the city of San Domingo.

[6][7][b] Cumby sent Tweed to Port Royal, where she arrived on the evening of 12 July with news of the French surrender on the 6th.

On 7 October 1809 Tweed seized the American schooner Success for a breech of the revenue laws.

[c] On 11 December Tweed seized the American schooner Daniel and Robert for a breech of the revenue laws.

[13] On 15 February 1811 Tweed captured the Danish vessels Anna Maria, Dorothea, Elizabeth, Concordia, and Active.

The cause of the wreck was due to the combination of an error in the soundings shown in the Admiralty chart and a strong current that had pushed Tweed inshore.