[3] Tynedale took part in the St. Nazaire Raid on 27 March 1942 as one of the escorts for the destroyer Campbeltown and small craft which were to enter the harbour.

[1] South west of Ushant she sighted the U-boat U-593 and attacked her initially with depth charges and then, when the submarine was forced to the surface, with a deck gun.

[4] When rendezvousing with the surviving small craft from the raid outside the harbour Tynedale and another destroyer, Atherstone engaged the five German torpedo boats of the 5th Flotilla.

[2] Tynedale was nominated for service in the Mediterranean, and as part of Destroyer Division 59 (which she joined on 8 March 1943) she guarded convoys between Gibraltar and Algeria.

She acted as an interceptor during the Allied invasion of Sicily, and aided in the rescuing of 218 passengers from the Dutch freighter Felix Jan Van Manix which was torpedoed and sank in October.