[1] The V-class were War Emergency Programme destroyers, intended for general duties, including use as anti-submarine escort, and were to be suitable for mass-production.

[21] Verulam formed part of the return convoy RA 57, with one merchant ship being sunk with the escort accounting for three U-boats.

[23] There were a large number of Allied merchant ships in Russian arctic harbour waiting to return to Britain, so Verulam was part of a strong force of warships that arrived at the Kola Inlet on 23 April, with orders to escort the merchant ships back to Britain and carry a large number of personnel, (including the US Navy crew of the cruiser Milwaukee, which had been loaned to the Soviet Navy, and Soviet crews for ships waiting in British harbours) with them.

[16][35] From 26 to 28 October, Verulam again escorted Implacable as the carrier's aircraft attacked shipping off Bodø, Rørvik, Lødingen and Kristiansund.

[16][36] On the night of 12/13 November, Verulam formed part of a task force led by the cruisers Kent and Bellona, together with the destroyers Myngs, Zambesi and Algonquin in Operation Counterblast, as they attacked a German convoy between Listerfjord and Egersund.

[37][38] Verulam was hit 22 times by German 37mm and 20mm shells, killing two and wounding five of her crew, although the ship's fighting efficiency was unaffected.

[16] After a work-up period at Scapa Flow, Verulam was sent to join the East Indies Fleet, arriving at Trincomalee and rejoining the rest of the 26th Flotilla on 4 April 1945.

[16][40] Verulam participated in the Battle of the Malacca Strait with the destroyers Saumarez, Venus, Vigilant, and Virago, which culminated in the sinking of the Japanese cruiser Haguro on 16 May 1945.

Between 1958 and 1961 Verulam was the Admiralty Surface Weapons Establishment (ASWE) trials ship,[41] being used for development of the Type 2001 sonar used by the Royal Navy's early nuclear submarines.

[44][45] In 1961 she was transferred to the 2nd Frigate Squadron based at Portland, operating as trials ship for the Underwater Weapons Development establishment (AUWE).

[44] Verulam was paid off on 21 December 1970 and sold for scrap to John Cashmore Ltd and arrived at their yard at Newport, Wales for breaking on 23 October 1972.