[6] This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).

The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs.

This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.

The HNRNPA2 and HNRNPB1 proteins are involved in packaging nascent mRNA, in alternative splicing, and in cytoplasmic RNA trafficking, translation, and stabilization.

[8][9] Function of HNRNPA2B1 gene can be effectively examined by siRNA knockdown based on an independent validation.