[5][6] This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).

The protein encoded by this gene has three repeats of RRM domains that bind to RNAs and also contains a nuclear localization motif.

[6] HNRNPR, together with its main RNA interacting partner, 7SK, is essential for axon growth in motoneurons.

[7] Depletion of HNRNPR from primary motoneurons inhibits axonal development, but it does not lead to enhanced loss of motor neurons.

[8] HNRNPR enhances c-fos transcription in vitro by forming a complex with PC4 and Mediator cofactors.