3BYH, 3D2U, 3J82, 3LUE6011461ENSG00000075624ENSMUSG00000029580P60709P60710NM_001101NM_007393NP_001092NP_031419Actin beta (HUGO Gene Nomenclature Committee abbreviation ACTB/ACTB) is one of six different actin isoforms which have been identified in humans.

Actins are highly conserved proteins[5][6] that are involved in cell motility, structure and integrity.

[8][9] In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding actin beta, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components.

Actin beta has been shown to activate eNOS, thereby increasing NO production.

[10] Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.