[1] Proteins in this family are typically found to contain two transmembrane segments (TMSs) and range between 70 and 80 amino acyl residues (aas) in length.
When the nucC operon carrying the nucEDC genes is placed in the Escherichia coli chromosome, NucE functions as a holin.
Additionally, NucE can complement lysis-defective bacteriophage mutants to allow for plaque formation and release of phage.
Although NucE can function as a holin it is not involved in the transport of nuclease, an extracellular protein encoded by the nucA gene.
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